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Simparica Trio for Dogs

Simparica Trio (Sarolaner, Moxidectin, Pyrantel)

Pet Size

Don't know your pet's weight?

If you can't get them on the scale, try this super simple method:

  1. Weigh yourself.
  2. Weigh yourself holding your pet.
  3. Subtract the two numbers to get their weight.

Too heavy to hold? Your vet will weigh them if you ask (or may already have it on file if you call).


No Prescription Required

  • Description

    Monthly Simparica Trio prevents heartworm disease, kills adult fleas and is indicated for the treatment and prevention of flea infestations, the treatment and control of tick infestations, and the treatment and control of roundworm and adult hookworm infections in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater.


    DOSAGE AND ADMINISTRATION SIMPARICA TRIO is given orally once a month, at the recommended minimum dose of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 µg/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt).


    •Sarolaner was first approved by the FDA in 2016 to treat and control flea and tick infestations. •Moxidectin was first approved by the FDA in 1997 for the prevention of heartworm disease in dogs. •Pyrantel Pamoate was first approved in 1977 for the treatment and control of adult roundworms and adult hookworms in dogs.

    Side Effects

    In a field safety and effectiveness study, SIMPARICA TRIO was administered to dogs for the prevention of heartworm disease. The study included a total of 410 dogs treated once monthly for 11 treatments (272 treated with SIMPARICA TRIO and 138 treated with an active control). Over the 330-day study period, all observations of potential adverse reactions were recorded.

    Frequently Asked Questions about Simparica Trio

    What is Simparica Trio?

    Simparica Trio is a monthly chewable tablet that combines sarolaner, moxidectin, and pyrantel to prevent heartworm disease, ticks, fleas, and roundworms and hookworms in dogs. It is FDA-approved to kill deer ticks that may transmit Lyme disease and has a liver-flavored taste that dogs love.

    Is Simparica Trio safe for dogs?

    Yes, Simparica Trio is considered fairly safe for dogs. Adverse reactions are rare, and most dogs take it without any problems. In safety studies, dogs responded well to the treatment.

    How does Simparica Trio work?

    Simparica Trio targets the nervous system of parasites, killing them quickly and effectively. It provides protection against fleas, ticks, heartworm disease, and intestinal worms.

    Why is Simparica Trio so expensive?

    Simparica Trio’s cost is due to extensive research, trials, production, marketing, patent acquisition, and quality. Its three-in-one formula makes it more comprehensive, contributing to the higher price.

    How long does Simparica Trio last?

    Simparica Trio lasts up to 35 days (5 weeks) from the day it has been administered. It provides continuous protection during this time, with a 5-day margin of error if you forget to give the next dose.

    Does Simparica Trio kill ticks?

    Yes, Simparica Trio effectively kills ticks, including deer ticks, Gulf Coast ticks, American dog ticks, and more.

    Does Simparica Trio kill tapeworms?

    Simparica Trio does not specifically treat tapeworms.

    How long does Simparica Trio take to work?

    It starts to kill deer ticks within 8 hours and fleas within 4 hours of administration.

    Can a dog overdose on Simparica Trio?

    While overdosing is unlikely, always follow the recommended dosage. Consult your veterinarian for specific instructions tailored to your dog’s health needs.

    How long do Simparica Trio side effects last?

    Common side effects, such as mild gastrointestinal upset (vomiting or diarrhea), usually resolve within a day or two after administration. Rare or severe side effects, although uncommon, may take longer to resolve. These could include allergic reactions, neurological symptoms, or other adverse effects. If you notice any unusual or severe symptoms, seek immediate veterinary attention.

    How often to give Simparica Trio?

    Administer one tablet to your dog every 30 days for continuous protection against parasites.

    Do you need a prescription for Simparica Trio?

    Yes, Simparica Trio requires a prescription from your veterinarian.

    Product Code : 13690