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Generic Product

Credelio Plus (Lotilaner+Milbemycin Oxime)

Pet Size

Don't know your pet's weight?

If you can't get them on the scale, try this super simple method:

  1. Weigh yourself.
  2. Weigh yourself holding your pet.
  3. Subtract the two numbers to get their weight.

Too heavy to hold? Your vet will weigh them if you ask (or may already have it on file if you call).


No Prescription Required

  • Description

    Credelio Plus is a prescription flea and tick medication for dogs that also prevents heartworms and other parasitic worms like hookworms, whipworms, and roundworms. This makes it an all-in-one parasite protection solution that requires nothing more from dog owners than giving their pet one of the flavored chewable flea and tick killer tablets once a month. The first active ingredient, Lotaliner, is absorbed into the bloodstream and kills fleas and ticks when they bite the animal. The second, Milbemycin oxime, is metabolized in the large intestine and kills worms there as they attempt to establish themselves in the larval stage.

    You can buy Credelio Plus with a prescription, and your best Credelio Plus price will be when your order it from World Pet Express.


    Give your pet one Credelio plus chewable once a month, and at the same time each month. Administer Credelio Plus with food or within 30 minutes of feeding to allow for the dog having peak blood levels and exposure.


    The active ingredients in Credelio Plus are Lotaliner and Milbemycin Oxime.


    Credelio Plus may not be suitable for dogs with a history of seizures or neurologic disorders, and this is something that should be discussed with your veterinarian before getting a prescription or starting on this flea, tick, and worm killer medication for dogs.

    Use of Credelio Plus may not be suitable for some breeds of dogs because of increased sensitivity to Milbemycin Oxime, and among them are collies, sheepdogs, and collie- or sheepdog-cross breeds. Your veterinarian will be able to discuss this in greater detail with you.

    Use with caution and only with veterinarian's approval for dogs that are breeding, pregnant or lactating


    There is the risk of negative drug interactions between Credelio Plus and other pet Rx medications, including cyclosporine, amidarone, diltiazem, azole antifungals, and erythromycin. It is advisable to inform your veterinarian of all medications your pet is currently taking before getting the prescription and proceeding to buy Credelio Plus.

    Side Effects

    Credelio Plus side effects are uncommon, but some dogs may experience lethargy, excessive drooling, pupil dilation, weight loss, elevated blood urea nitrogen, increased urination, or diarrhea. If Credelio Plus side effects are seen, you may want to discontinue use and speak to your veterinarian again regarding full spectrum parasite protection for dogs alternatives.

    Frequently Asked Questions about Credelio and Credelio Plus

    What's the difference between Credelio and Credelio Plus?

    Credelio Plus is an advanced version of the chewable tablet Credelio. It contains two main ingredients: milbemycin oxime (for gastrointestinal worms) and lotilaner (for fleas and ticks). Credelio Plus also prevents heartworm and lungworm infections.

    How often do you give Credelio Plus to dogs?

    Administer once a month with or after food. Dosage varies based on your dog’s weight and age. Consult your vet for personalized dosing instructions.

    What does Credelio Plus do for dogs?

    Credelio Plus kills fleas and ticks persistently for a month, protects against roundworms, is effective against adult and larval stages of gastrointestinal worms, and prevents heartworm and lungworm disease.

    What does Credelio Plus not cover?

    Credelio Plus does not cover adult D. immitis (heartworm) and is not indicated for microfilariae clearance.

    Is Credelio safe for dogs?

    Generally safe, but avoid in breeding, pregnant, or lactating dogs. Consult your vet for personalized advice.

    What are the side effects of Credelio Plus?

    Possible side effects include gastrointestinal upset (vomiting or diarrhea), loss of appetite (usually temporary), increased thirst (polydipsia).

    Why does Credelio have to be given with food?

    To enhance palatability and ensure proper absorption. Administer with or after food.

    Can dogs still get ticks on Credelio?

    Credelio is effective against ticks, including those that transmit diseases.

    How long does Credelio Plus take to work?

    Credelio Plus starts killing existing fleas within 6 hours and can kill new flea infestations within 4 hours. It breaks the flea life cycle by killing before fleas can lay eggs.

    Is Credelio safe for older dogs?

    Consult your vet to assess safety based on your older dog’s health and specific needs.

    Product Code : 13571

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