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Advantage for large cat

Advantage II for Cats (Imidacloprid / Pyriproxyfen)

Pet Size

Don't know your pet's weight?

If you can't get them on the scale, try this super simple method:

  1. Weigh yourself.
  2. Weigh yourself holding your pet.
  3. Subtract the two numbers to get their weight.

Too heavy to hold? Your vet will weigh them if you ask (or may already have it on file if you call).


No Prescription Required

  • Description

    Fleas are as much of a nuisance for cats as they are for dogs, and cat owners will want an effective flea medication for cats that they can rely on to rid their pet of these nasty little insects. Advantage II for cats is just what they’re looking for, and it’s earned its spot as one of the best flea medications for cats these days. That’s because not only is it a good flea killer medication, but it also is able to eliminate these pests at all life stages. It kills flea eggs and larvae too, so when you give your cat their once-a-month application you can count on seeing long-lasting relief from fleas.

    Advantage II for cats has the ability kill 98+% of fleas within 12 hours of being applied and applying this quality flea medication for cats couldn’t be any easier.


    Apply Advantage II for cats once a month and apply the entire contents of each application pack directly to the pet’s skin and beneath its fur right at the base of the skull/top of the neck.


    Imidacloprid 9.10%, Pyripoxyfen 0.46%


    This topical flea medication is for external use only and is harmful if swallowed. It may also cause eye irritation so be sure to handle the product carefully. Wash your hands with soap and water after handling and keep out of reach of children and away from food. Plus, if your pet is taking any other medication it is best to discuss possible interaction risks with your veterinarian before beginning use of Advantage.


    There are no known interaction risks between use of Advantage II for cats and any other Rx pet medication but it is recommended to discuss all medications your pet is currently taking when speaking with your veterinarian about fleas medication.

    Side Effects

    Side effects from use of Advantage II for cats are uncommon, but may include skin irritation, gastrointestinal issues like vomiting, diarrhea or hypersalivation, and lethargy. If any of these symptoms continue or worsen you should see a veterinarian.

    Frequently Asked Questions about Advantage II

    What does Advantage II do?

    Advantage II is a topical flea treatment for cats and dogs. It kills fleas through contact, meaning fleas don’t have to bite your pet to be eliminated. Advantage II also prevents flea eggs and larvae from developing into the next stage of the flea life cycle, effectively controlling infestations.

    What is the difference between Advantage and Advantage II?

    Advantage II is an improved version of the original Advantage. The key difference lies in the addition of an active ingredient called pyriproxyfen in Advantage II. This ingredient targets flea eggs and larvae, enhancing its effectiveness in breaking the flea life cycle.

    Does Advantage II expire?

    There is no required expiration date on the packaging for Advantage II. It remains stable and effective for a long time. You can use older batches as long as they were purchased after the release of Advantage II in March 2011.

    How does Advantage II for cats work?

    Advantage II contains imidacloprid and pyriproxyfen. Imidacloprid kills adult fleas by affecting their nervous system, while pyriproxyfen inhibits flea egg and larvae development.

    How long does Advantage II take to work?

    It starts working within 12 hours and provides continuous protection for 30 days.

    How to apply Advantage II on cats?

    Apply Advantage II directly to your cat’s skin between the shoulder blades. It’s essential to follow the instructions provided in the pack or consult your veterinarian. Remember to record the treatment date and repeat monthly.

    Does Advantage II kill ticks?

    Advantage II primarily targets fleas, but it does not specifically kill ticks. For tick control, consider using a separate tick prevention product.

    Is Advantage II safe for cats?

    Advantage II is safe for cats when used as directed. However, always monitor your cat for any signs of irritation or adverse reactions after application.

    Is Advantage II prescription only?

    Advantage II is available over the counter and does not require a prescription.

    Can I apply Advantage II twice a month?

    Apply Advantage II once a month. Applying it more frequently than recommended is not necessary and may not provide additional benefits.

    Product Code : 12335